Background: The incidence of Type 2 DM (T2DM) is rapidly increasing worldwide and constitutes a major global public health problem. Autonomic reactivity to a challenge like that of exercise or cold offers a greater scope to evaluate and assess the capability of autonomic system to regulate and maintain homeostasis. The cold Pressor test (CPT) which is considered to be a sympatho-excitatory maneuver is a simple, noninvasive and validated test of sympathetic activation. The Blood pressure (BP) responses to CPT could be used as indicators of global sympathetic activation, and thus of cardiac status and autonomic function. Aims: To compare the autonomic reactivity by recording the Blood pressure during and after CPT between healthy offspring with and without parental history of T2DM. Methods: This study consists of 40 healthy male subjects with family history of T2DM (cases) and 40 healthy male subjects without family history of T2DM (controls) in the age group of 18-25 years. BP during and after CPT were compared between cases and controls. Results: Chi-square/ Fisher Exact test has been used to find the significance of study parameters on categorical scale between two or more groups. In the present study, the post CPT changes in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) did not demonstrate any significant differences. However, the graphical representation of SBP changes after CPT shows fluctuation among cases before it reaches the stable value, whereas, in controls the decrease was at constant level. Conclusion: The results suggest there was altered autonomic reactivity to physical stress among the offspring with parental history of T2DM when compared to their counterparts and hence this points towards the fact that they are at a risk of developing future autonomic dysfunction and cardiovascular complications.