Microbes have ecological interactions with almost all life forms. Likewise, humans invariably engage in host-microbial interactions that could induce short-term or long-term effects. They are used in pharmaceutical industries for the synthesis of chemical compounds. Nowadays, chemical industries using the bacteria to synthesis the industrial products like. Some important features of bacteria in food industries remain unclear. This review highlighted the role of bacteria in industries for synthesis of compounds in medical as well as industrial point of view but some of the bacterial species have great impact on the human health thus causing serious diseases in human. Lactic acid bacteria (LAB) is used to produce cheese, yoghurt, kefir and kimchi. Acetic acid bacteria (AAB) is used in traditional manufacturing of vinegar. Bacteria are used to create multiple antibiotics such as streptomycin from the bacteria streptococcus. Another important role in pharmaceuticals is the use of microbes for the medically important studies, such as bacteriorhodopsin. Escherichia coli is used for commercial preparation of riboflavin and vitamin K.E. coli is also used to produce D-amino acids such as D-p-hydroxyphenylglycine, an important intermediate for synthesis of the antibiotic amoxicillin.