Objectives: To assess the feasibility of self mouth examination (SME) in case finding of oral cancers and potentially malignant disorders (OPMD) among high risk rural population in India. Materials and methods: 15,000 pretested pictorial handout (brochure) with instructions (local language) depicting the signs of oral cancer and self mouth examination procedures were distributed among every households (n= 3500), People were also demonstrated self mouth examination (SME) technique. One week later a three day cancer detection camp was carried out. Individuals were instructed to conduct self mouth examination (SME) and report the cancer detection camp if any questionable lesions were noticed. Individuals who reported were screened for oral cancer with the use of toluidine blue vital staining, oral exfoliative cytology and final diagnosis through biopsy. Results: The total population consisted on 579 individuals out of which 372 (64.25%) were males and 207 (35.75) were females. The total percentage of self mouth examination (SME) performance was 95.34%. 53.20% of the study population identified suspicious lesions in the oral cavity. After thorough oral examination, malignant lesions like oral cancer (2 cases) and many cases of oral potentially malignant disorders were found. The sensitivity of mouth self examination was 48.66% where as the specificity was 44.75%. The positive predictive value was 23.54% where as the negative predictive value was 71.37%. Conclusions: Self mouth examination is an effective tool which can be used in the case finding of oral cancers and oral potentially malignant disorders.