Viruses as pathogens have ability to replicate in the particular host in order to damage their organs. Some bacterial pathogens cause lethal diseases associated with metabolisms. Bacteria also increase the rate of infection due to antibiotic resistance. There is need to design such drugs that control the specific targets of bacterial strains. Streptococcus type also causes the diseases associated with medical conditions such as pneumonia. Shigella as well as Salmonella also causing the diseases in food and food products. Pseudomonas syringae as one of the bacterial pathogens that attacks on the leaves as well as different parts of plants that finally damaged to whole plant. S. pneumoniae is the pathogenic bacterial strain that causes severe inflammation in the lungs by damaging to the lungs. E. coli as the type of bacterial pathogen that enter into the intestine of the human. It particularly stays here and multiplies to increase its infection to damage the specific parts of intestine. Chikungunya virus is spread to people by the bite of an infected mosquito. The most common symptoms of infection are fever and joint pain. The DENV genome is about 11000 bases of positive-sense, single stranded RNA (ssRNA) that codes for three structural proteins. At present, CYD-TDV or Dengvaxia® is the only approved vaccine, but potent inhibitors are currently under development.