Background: The eye is supported to be the second organ to manifest drug toxicity following liver. Systemic drugs are frequently administered in persons of all age group ranging from children to the elderly for various disorders. There has been increased reporting of ocular side effects of various antipsychotic drugs in the past two decades. Psychiatrists, ophthalmologists and patients need to be aware of and prepared for any medication-induced toxic effect. Early prevention and intervention can avoid most of the serious and potentially irreversible ocular toxicities. Objective: The aims of the present study were to evaluate the occurrence of toxic ocular effects of antipsychotic drugs, evaluate intraocular pressure of chronic psychotic patients treated with psychiatric medications, correlate toxic ocular effects in patients treated with a variety of antipsychotics to duration of treatment. Methods: The present study was conducted on 100 chronic psychotic patients attending the Dr. Sirajul Islam Medical College and Hospital Ltd, Dhaka, Bangladesh who on treatment of antipsychotic drugs for a period more than six months period with age group between20 - 60 years. Data was entered in MS Excel and Statistical analysis was done using SPSS trial version 22. Results: 14% of those patients were on typical therapy alone, 16% on atypical antipsychotic alone while 70% were on combined therapy. As regard lens opacity, 7% was suffered from lens opacity, six cases due to typical therapy while one cases due to atypical therapy. Intraocular pressure was manifested in 11% of all cases. Optic disc examination revealed two cases had increased cup disc ratio who on typical therapy alone. Conclusion: It can be concluded that many systematic drugs can produce ocular and visual side effect which range from mild to severe and can be even vision threatening.