Thyroid diffuse large B cell lymphoma (DLBCL) presents typically as a rapidly growing neck mass that is sometimes accompanied by respiratory compression symptoms. It is more predominant in women and has a peak onset age of 50 to 70 years [1]. DLBCL should be treated with chemotherapy and radiotherapy after diagnosis through biopsy, and extensive surgery should be avoided. Here we describe a rare case of 63-year-old woman who was admitted in our ENT department due to rapidly growing (2 months), painful thyroid enlargement with compressive cervical symptoms.