Marine sponges are on focus for their ability to produce compounds with antimicrobial activity. The aim of the current study was to screen extracts derived from marine sponge Sigmadocia fibulata (Schmidt) and Suberites carnosus (Johnston) for their activity against selected bacterial fungal and pestecidal pathogens. The crude extract derived from Sigmadocia fibulata (Schmidt) and Suberites carnosus (Johnston) were found potent against tested E. coli and P. mirabilis bacteria. The crude extract of both the sponges showed pasticidal activities against Periplanata Americana and Sitopbilus oryzae. No activity was noted against fungus when tested with crude extract of Sigmadocia fibulata (Schmidt) and Suberites carnosus (Johnston). Thus confirms that the crude extract of Sigmadocia fibulata (Schmidt) and Suberites carnosus (Johnston) have antibacterial and anti pesticidal property.