Background: Smoking is a well-recognized risk factor of CAD, angiographic profile and traditional risk factors among smoker patients varies, along with their clinical presentation and outcome. Objective: This study has been conducted to focus on the angiographic profile of smoker patients presenting with CAD and to explore the prevalence of their additional of risk factors. Method: This study has been enrolled among 328 smoker patients with CAD presenting to ER of SSH-cardiac Center/ Erbil from Jan 2017 to March 2020. Results: The study population was composed of 320 males (97.6%) and 8 females (2.4%). The mean age was 39.07+12.3 years, with an age range of 20-75. The results showed that smoker patients with CAD had occlusive CAD (79.3%). The prevalence of most commonly occluded artery was LAD (43.8%) during CoA presenting with AWMI. The prevalence of risk factors was, Hypertension (37.8%), positive family history (40.2%), high levels of LDL (53.7%), Lowered levels of HDL (31.7%), elevated levels of TC (31.7%), elevated levels of TG (29.3%). It was noted that 29.3% were Diabetic, and according to the HbA1c levels, of 34.1% was diabetic, this clarifies that 4.8% of the smoker patients were undiagnosed DM (Newly diagnosed DM). Conclusion: Smoking is associated with the angiographic profile, traditional risk factors and their clinical outcomes. AWMI was mostly observed among smoker patients owing to LAD lesions.