Background: The morphometric parameters of mandibular ramus play an important role in predictive variable in sex determination of mandible. Aim: to study the morphometric predictability of mandibular ramus in sex determination of mandible. Materials and Methods: 40 dry human mandible bones of unknown sex were utilized to study the height and breadth of the ramus of mandible and its accuracy factor in sex determination. The dry mandible bones were collected from the Department of Anatomy as well as from the undergraduate students of Santhiram Medical College & Hospital, Nandyal. The parameters like height, breadth of the mandibular ramus were measured by using sliding calipers. Results: The height of the ramus of mandible on the right side was 108.85 + 9.84 and on the left side, it was 108.82 + 9.89 in the present study. The maximum breadth of ramus was 43.62 + 5.09. The minimum breadth of ramus was 57.85 + 8.08. Conclusion: Morphometric variations of mandibular ramus may be an important anatomic factor for sex determination and unfavorable anatomic factor in difficult laryngoscopy.