Virus uses components of the host cell to complete its life cycle. Some viruses can cause or contribute to the development of cancer. Unlike other viruses, such as influenza viruses, that cause an acute infection, oncogenic viruses often cause long-term, persistent infections. Several studies also involved in the toxicity in progression of cancer caused by different microbes. Microorganisms and their metabolic byproducts, or impact of chronic inflammation, may also be linked to oral cancers. Helicobacter pylori colonize the human stomach and duodenum. In some cases it can cause stomach cancer. Salmonella Typhi has been linked to gallbladder cancer but may also be useful in delivering chemotherapeutic agents for the treatment of melanoma, colon and bladder cancer. Saponins reduced the risks of the occurring of the cancer during advanced age. It has special structure that active for the frightening against the cells of the cancer. The concentrations and attacking power of the microbes as well as the other pathogens directly related to the concentration of the compounds such as the saponins that taken through diet as the right composition. Saponins in other way acting as the antioxidants to prevent the cancer. When the cells of the cancer attacked on the normal one then became difficult to stop the process of the metastasis. Saponins also showed activity against the nonfunctional cells of the lungs that have been attacked due to certain cause’s cancer.