Bridelia retusa commonly known as Khaja or Kasai in India, belonging to the family Euphorbiaceae, is a tropical small-sized tree found throughout warmer parts of India. Entire parts of Bridelia retusa has been traditionally used for healing of several ailments such as rheumatism, diabetes, diarrhea, dysentery, removal of urinary concretions, and the bark of the plant is used by tribal people to develop sterility as a contraceptive. The present investigation was planned to evaluate and explore potential bioactive phytocompounds in the bark, fruit, and leaf extract of Bridelia retusa using phytochemical profiling and an infra-red spectrophotometer. The phytochemical evaluation of bark, fruit, and leaf extracts of Bridelia retusa revealed the presence of alkaloids, cardiac glycosides, flavonoids, saponins, steroids, tannins, and terpenoids in extracts. All seven phytocompounds were found in both aqueous leaf and methanolic bark extracts. Alkaloid was detected in all except for ethyl acetate extract. Cardiac glycosides were found in extracts of aqueous and petroleum ether. Steroid and terpenoids were detected from all aqueous and methanol extracts whereas saponin was found in all aqueous extracts. FTIR spectrophotometric analysis exhibited the presence of primary & secondary alcohols, alkenes, aldehyde, primary & secondary amines, aliphatic bromo compounds, aliphatic ether, aromatic amines, acid halides, ester, halo compounds, vinyl ether, and aromatic compounds. The presence of these phytocompounds suggests better possibilities for the plant as a source of significant phytomedicines in pharmaceutical industries and research institutes for the discovery of lead compounds for a competent drug.