Meditation produces various effects on human physiology, which are mediated via autonomic nervous system. Meditation is a simple and scientific technique to elicit physical and mental relaxation response, to change one’s attitude and transform life-style. Regular practice of it brings transformation in overall wellbeing of person. The cardiovascular morbidity is increasing in India in recent years. The present study was done to know the effect of meditation on heart rate and blood pressure in healthy volunteers above the age of 35 years. The cardiovascular status of the subjects was assessed clinically in terms of resting heart rate and blood pressure before the start of meditation practice and again after 4 months of practice of meditation. The results were compared and analysed.. From the study it was observed that significant reduction in the heart rate occurs in the subjects practicing meditation (P < 0.001). The systolic blood pressure was lowered to a highly significant level (P < 0.001). The diastolic blood pressure was reduced significantly (P < 0.001). This shows that the yoga provides significant improvement in ageing to reduce the morbidity and mortality from cardiovascular diseases. Meditation provides significant improvements in physiological cardiovascular functions by tilting of autonomic balance from sympathetic in favour of parasympathetic.