Atorvastatin is lipid lowering drug use in different cases to prevent complications of hyperlipidemia by lowering lipid mainly affect cholesterol, but it also affect in concentration of other serum parameters such as uric acid and creatinine. Case-control study was conducted during the period between Marchs to May 2017, included 100 participants 60% cases and 40% control with age between (20-70) years. Case group included 62% female and 38% male, used different doses (10, 20 and 40 mg/day) and different durations using for variable conditions such as (DM, HTN or protection for risk of CVD). Control group was matched for cases group but not used any lipid lowering drugs. The result of this study showed that significant association between atorvastatin uses and decrease in UA, Cr, T.Chl and LDL (P-value: 0.000, 0.020, 0.015 & 0.018 respectively). Decrease in all parameters by increase dose but not significant only significant with dose 40 mg/day (p-value: 0.037, 0.044, 0.044 & 0.005 respectively). Decrease in Cr, TCh and LDL by increasing the durational of atorvastatin intake and concentration (P= 0.042, 0.001 & 0.000 respectively). Significant relation was detected between combination DM & HTN and increase UA (4.55±0.87) & Cr (0.69±0.16) (P-value: 0.032 & 0.015 respectively) no significant relation with T.Chl and LDL (P-value: 0.636 & 0.594 respectively). Significant decrease in UA, Cr, T .Cho & LDL mean concentration found among atorvastatin user and the dose 40mg/day is highly significant effect. No correlation between durational of atorvastatin used and the parameter concentration. A more research should be done to detect specific correlation between atorvastatin and this parameters.