According to WHO estimates, 16.7 million people around the globe die of cardiovascular disease each year. Economic transition, urbanization, industrialization and globalization bring about life style changes that promote heart disease. High blood pressure, high cholesterol and obesity are likely to become more prevalent in developing countries. Increased energy intake and sedentary lifestyle are also responsible for heart disease. The presence of one or more cardiovascular risk factors like high levels of TC, LDL, TG, glucose, insulin, BMI and a decreased HDL have been found to increase the progression of prehypertension to hypertension. Prehypertension increases the risk of MI and CAD. The present study was undertaken to know serum HDL changes in prepubertal and postmenopausal women. Life style patterns like diet, physical activity were included in study. Total 60 Subjects of age group 8-10Years (prepubertal), 46-55years (postmenopausal) female volunteered for our study. During the study period, BMI, HDL, dietaty intake and physical activity and parameters were recorded in all the subjects. HDL is gradually decreased from pre pubertal to post menopausal women. We concluded the presence of Cardio protective HDL is normally higher in prepubertal females. Lower levels of HDL increases CVD risk. This can be attributed mainly to sedentary life style, stress and dietary habits this is seen in post menopausal women.