The world has experienced major deadly pandemic which proved bruatual killer of various intensities such as Antonine flue in 168 AD, than Black Fever, Cholera Asian/Russian flue, HIV/AIDS. Now recently in Dec. 2019 a noval coronavirus called as Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2) emerged in the Wuhan City of China, and rapidly spreaded worldwide, and on March 11, 2020, World Health Organisation (WHO) decleared COVID-19 a world pandemic. As no vaccine or drug is available to eradicate the virus, and as such researchers and scientist of different countries are in the race of preparation of vaccine to eradicate this pandemic and experimenting with drugs and therapies to help ease the strain on hospitals and intensive care units. Some drugs that are indicated for other afflictions seems to be potentially beneficial to treat the infection albeit without unequivocal evidences. Thus the present article is compared with the objective to review the published literature on the effectiveness of these drugs against COVID-19 which is need of honour.