Despite the challenge, some complex surgical interventions will require a general anaesthesia which must be of rapid onset and recovery qualities to minimize the risks. Propofol, a phenolic compound meets the requirement of general anaesthetic agent in ruminants with its rapid onset and recovery properties and minimal effect on the vital and haematological parameters. Propofol has been used without adverse effects on cardiopulmonary and haematological parameters in pregnant goats. Like in other breeds of goat studied, we therefore hypothesized that propofol has no adverse effects or cardiopulmonary system and haematologic parameters and is safe for pregnant Red Sokoto goats. Five (5) healthy pregnant Red Sokoto does (19±0.6kg) were acquired for the purpose of this study and stage of pregnancy was ascertained with the aid B-mode real time transcutaneous ultrasonography. After 14 days of acclimatization, propofol anaesthesia was induced at 4 mg kg-1 and maintained at 0.4 mgkg-1min-1 continuous infusion rate for 60 minutes. Vital parameters were taken using the standard procedures and blood samples were collected through a pre-placed intravenous catheter at pre-induction period (0 minute) to serve as the baseline and at 5, 10, 15, 30, 45, 60 and 120 minutes during anaesthesia. Statistical analysis showed no significant difference (P>0.05) for all the parameters measure except the respiratory rate, MCV and MCH that increased significantly (P<0.05) at the 120 minute period of observation. We therefore concluded that propofol is safe for anaesthesia in pregnant RSG with minimal to no effect on vital and haematological parameters.