The leaves of most plants contain two highly differentiated cell types in the epidermis guard cells, which constitute stomata, and trichomes. These cells, the spacing of which is the primary focus are usually separated from each other by pavement cells. Our understanding of the response of angiosperm stomata to environmental parameters remains imprecise because we know little about the mechanisms of stomata control modules. This research was carried out in the old Botanical Garden of the Agriculture University, Faisalabad from January 2019 to June 2019 to examine morphological studies of selected dicots plants leaves with biological active compounds for treatment of cancer using the compound light microscope also to predict algometric relationships between morphologically stomata traits in relation to gaseous exchange in leaf and required allocation of epidermal area to stomata. Epidermal cells varied from round, square to hexagonal with distinctive anticlinal cell wall and sunken stomata distributed on adaxial and abaxial were observed. Stomata are present in the upper and lower surface of the leaves helpful as adaptation for plants during photosynthesis process and stress condition to maintain the water usage.