The objective of this study was to evaluate the anti-inflammatory and antioxidant activities of ethanolic and palm wine extract of Phragmanthera capitata stems widely used by traditional healers. Acute toxicity according to the OCDE Guideline 423 showed that the LD50 of ethanolic and palm wine extract was greater than 5000 mg/Kg body weight. Anti-inflammatory capacity was evaluated by hind paw oedema model using carrageenan-induced inflammation in rat. It has showed that palm wine and ethanolic extracts possessed a dose-dependent anti-inflammatory activity (at the first hour) with 21.47% and 41.24%, respectively, as a percentage inhibition for the 200 and 300 mg/Kg body weight of palm wine extract and 16.95% and 28.21% for the ethanolic extract of same dose as compared with 25.42% for aspirin. The phenol dosage by the Folin-Ciocalteu method showed that ethanolic extract (14420 mg EAA/g dry extract) had a high content relative to the palm wine extract (2570 mg EAA/g of dry extract ). The antioxidant capacity was evaluated by the diphenyl-picryl test (DPPH), where the ethanolic extract showed strong antioxidant activity with a EC50 of 0.0085 mg/mL when that of the wine extract was 0.049 mg/mL, after the ascorbic acid (standard) with 0.033 mg/mL. Ethanolic and palm wine extract of Phragmanthera capitata stems are non-toxic and have inflammatory and antioxidant activity that could justify its traditional use.