Haya: The Saudi Journal of Life Sciences (SJLS)
Volume-3 | Issue-05 | 437-442
Original Research Article
Antihyperglycemic and Antilipidemic Activity of Solanum torvum Roots
Jitendra Debata, H.K Sundeep Kumar
Published : May 30, 2018
Abstract
Ethanolic root extract of Solanum torvum Sw (Family: Solanaceae) was
evaluated for its antihyperglycemic and antilipidemic activity in streptozotocin
induced diabetic rats. The extract was given orally in two different doses (200 and 400
mg/kg) for 28 days. Metformin (2.5 mg/kg) was used as a standard drug for activity
comparison. Various parameters studied were blood glucose concentration, serum
lipids, glycosylated haemoglobin and liver glycogen. The extract showed significant
antihyperglycemic activity in dose dependent manner. Further, the extract was
favourably and significantly corrected the alterations in the values of the lipid
parameters, organ weights, liver glycogen and glycosylated haemoglobin content in
diabetic rats. Therefore, it may be suggested that the ethanolic root extract of Solanum
torvum has potential ability to prevent the secondary complications of diabetes
mellitus like atherosclerosis.