Wide range of inter-annual climatic variability and frequent occurrence of extreme climatic events is a great concern. There is a need to assess the impact of such events on agriculture and to suggest suitable agri-management options for sustenance. The appropriate regional based agro-advisory needs to be established for the farmers and other stake holders. Inter-annual climatic variability has to be linked through growth and yield of crops and cropping systems in various production environments of Bangladesh. Climate change is a global concern, and we must identify vulnerable regions as well as identify suitable mitigation and adaptation strategies through various agronomic and management options to sustain the agricultural production. Development of climate resilient agriculture is of paramount importance. Agri-response must be evaluated in relation to future climate change scenarios, in which crop modelling can play an effective role. With the help of crop simulation tools, assessment can be made for newer production centres and identifying suitable resource management options for maximizing production. Impact of climate change needs to be worked out on regional scales by integrating crop models with relational layers of bio-physical and socio-economic aspects. For this purpose use of geographic information system (GIS) and remote sensing tools is needed. In this review article, we have discussed about the inter-annual climatic variability and occurrence of extreme climatic events in Bangladesh and their association with agricultural production system. In this paper, we have demonstrated the potential of crop models viz. INFOCROP, DSSAT to assess the impact of this climatic variability and its change on growth and yield of crops and cropping systems and thereby suggesting appropriate management options for sustenance.