Tabernaemontana divaricata is commonly used for the treatment of various illnesses. In the present study crude flower extracts were made using four different solvents such as water, methanol, ethanol and chloroform and were subjected to preliminary phytochemical analysis .Well diffusion method was used for screening of the antimicrobial activity against selected oral pathogens such as Streptococus mutans, Streptococcus salivarius, Streptococcus mitis and Lactobacillus acidophilus. Results showed the presence various phytochemicals including alkaloids, tannins, reducing sugars, saponin, steroids and triterpenoids and proteins. Among these extracts, methanol extract showed significant antibacterial activity against most tested bacteria. The weakest activity was seen in the acetone extracts.