Giardia is a common protozoan parasite infecting children in developing countries and is known to result protein loss in infected children. The objective of this study was to assess the association of plasma protein profile with Giardiasis among children in district Anantnag of Kashmir valley. The study included 268 children aged 5-15 years belonging to both the genders. Stool samples collected from children were screened for Giardia infection and blood samples were analysed to estimate plasma protein, albumin and globulin levels. The results showed a significant decrease in mean values of total protein between infected and uninfected children from 6.71±0.96 to 7.01±0.98. The mean values of albumin also showed a decrease in their values between infected and uninfected children from 3.7±0.45 to 4.21±0.51 and that of globulin showed an increase in mean values from 3.01±0.91 to 2.8±0.58 between infected and uninfected children. However the difference was statistically insignificant (p> 0.05).