Chrysophyllum albidum and Irvingia gabonensis have been reported to possess several medicinal values. Most studies on these plants have focused on the fruits rather than the leaves. The present study therefore, evaluated the phytochemical constituents and in vitro antioxidant activity of methanol leaf extracts of Chrysophyllum albidum and Irvingia gabonensis. Photochemical screening was carried on the plant samples using established protocols.The results of the phytochemical screening of both extracts revealed the presence of saponins, flavonoids, alkaloids, steroids and tannins. Terpenoids and cardiac glycosides were below detectable levels in both extracts. Irvingia gabonensis extract showed significantly higher (p<0.05) levels of total phenol, total flavonoid and total tannin than the Chrysophyllum albidum extract. However, there was no significant difference (p>0.05) in the proanthocyanidin content of both plant extracts. Irvingia gabonensis extract had a significantly higher (p<0.05) ferric reducing antioxidant potential (FRAP) value and was a better 1,1–diphenyl–2–picrylhydrazyl (DPPH) radical scavenger than Chrysophyllum albidum extract. The results of the study revealed that extract of Irvingia gabonensis had more phytochemicals and consequently, possessed higher antioxidant activity than Chrysophyllum albidum extract.