A stroke is the rapid loss of brain functions due to disturbance in the blood supply to the brain. In the last few years a great deal of research has been carried out to find the effectiveness of herbal drug for the treatment of stroke. Both thrombolytic and neuro-protective properties of herbal drugs may be a novel strategy for effective stroke therapeutics. The animals were divided into five groups of six each. Except the normal and control groups, all other test groups received different doses of aqueous extract of Hugonia mystax orally for 45 days as per the treatment schedule.Animals were observed for behavioral parameters after 24 hours of surgery in three different areas, neuromuscular function, vestibule motor function, and complex neuromotor function which consists of various subtests such as forelimb flexion, twisting, resistance to lateral push, circling, hind limb placement, forelimb placement, pinna reflexes and corneal reflexes.The remaining animals in each group were also sacrificed after 72 hours post-surgery by cervical decapitation. The brains were excised and used for the estimation of Lipid peroxidation, Superoxide Dismutase and Catalase.Hugonia mystax, a rich source of antioxidant consists of dietary fibers, flavonoids, proteins, vitamins like vitamin B1 and minerals like iron, copper, magnesium and potassium. It is also an excellent source of molybdenum and folate. The present study results support that Hugonia mystax has dose dependent stroke preventive activity in common carotid artery occlusion along with ferric chloride induced thrombosis model.