Self-Medication is an important phenomenon worldwide. In addition to its advantages, it is associated with some risk when medicines are misused or abused. Students may not have the sufficient knowledge about medications that is why the resultant side effects can be very serious. The study mainly aims to evaluate the knowledge and attitudes of high school and university female students (Taif City, KSA) towards the use of medicines during Exams. A self-administered as well as an electronic questionnaire was used to collect responses from the students in March 2017. Total of 363 students were randomly selected and from the university and four high schools and recruited in the study. Respondents recruited with face-to-face questionnaires were 241 (66.4%), compared to 122 (33.6%) included electronically. The statistical package for Social Science (SPSS) version 22 was used to analyze the study data. The study showed that about 48.5% of the female students agreed that exams affect their health status and food habits to a large extent and about 56% suffer from anxiety during exams. The most prominent health problem during exams was headache (44.3%) followed by stomach pain (27.8%) and respiratory problems (15.9%). Few students (15%) agreed that using medicines would improve their performance, while (31.4%) answered that side effects of medication negatively affected their academic performance. The most common drugs used by students during exams period were antihistamine (49%), followed by painkillers (8%), and antibiotics and medicines for chest illness (6.3%). There is a high prevalence of irresponsible self-medication among high school and university students, with observed side effects. There is a need to raise the students’ awareness about medicines at school, university and homes.