Introduction: The rational use of antibiotics is a major concern due to the development of bacterial resistance and the emergence of multiresistant bacteria. The objective of this study is to evaluate the consumption of antibiotics within the HMMI for 3 years (2016 to 2018). Materials and Methods: This is a retrospective study of the consumption of antibiotics for 3 years (2016 to 2018), allowing the distribution of hospital services in 5 activity sectors; whereas the calculation of antibiotic consumption in DDJ / 1000JH made it possible to determine the overall consumption of all antibiotics of the HMMI in DDJ / 1000JH for the years 2016-2017-2018; to determine the consumption by antibiotic families of HMMI in DDJ / 1000 JH for the years 2016-2017-2018; to determine the average consumption by antibiotic families and by activity sectors in DDJ / 1000JH. Results: The analysis of the overall consumption of all antibiotic families combined showed a consumption of 861.38 DDJ / 1000JH in 2017 and 700.97 DDJ / 1000JH in 2018. While the calculation of the percentage change between the years 2016 and 2018 revealed a decrease in the overall consumption of antibiotics by (-9.07%). Analysis of consumption by families of antibiotics has shown that betalactamines are the most prescribed molecules with 77.39% or on average (601.86 DDJ / 1000JH); monitoring of fluoroquinolones with 7.21% or on average (56.08 DDJ / 1000JH); monitoring of aminoglycosides with 6.44% or on average (50.12 DDJ / 1000JH). Analysis of the overall antibiotic consumption by sector of activity has shown that the resuscitation sector is the sector most prescribing antibiotics of all families, with an average of 1345.61 DDJ / 1000 JH. Discussion: The results of our work showed high consumption, explained either by an adapted prescription policy or overconsumption by inappropriate prescriptions. Various surveys show that 20 to 50% of prescriptions for antibiotics are inappropriate in hospitals. Conclusion: The link between the use of antibiotics and the emergence of bacterial resistance is clear The present retrospective study was an important assessment. Which must be supplemented by prospective studies evaluating the quality of prescription at the level of the services most consuming antibiotics.