Age-related macular degeneration (AMD) is a progressive degenerative retinal disease with particular damage in the macular area. It is the most common cause of blindness in developed countries mainly affecting the elderly. The exudative or wet form represents the most severe form with rapid progression despite therapeutic progress. It is characterized by the development of choroidal neovessels, crossing the retinal pigment epithelium and developing below the macular area. We report a clinical case of exudative AMD complicated by macular edema and serous retinal detachment, diagnosed in a 70-year-old patient with cardiovascular risk factors and presenting reduced visual acuity with central scotoma. Through this case we study the risk factors, the diagnostic and therapeutic procedure of exudative AMD with a review of the literature.