The contribution of phytotherapy to solving hemorrhoidal problems is incontestable because of the richness of plants as secondary metabolites. However, it is important to know the pathophysiology of this disease in order to give effective drug recipes for its treatment. In order to understand the different aspects of hemorrhoidal diseases and to identify plants used for its treatment, an ethnobotanical survey was carried out among trade-practitioners of the Southeastern region of Cameroon. During data collection, information was collected on hemorroidal diseases and plants used for its treatment. The relative importance (RI) of the plants was indicated and the phytochemical screening of the plants of interest was performed. Patients who approached trade-practitioners to seek treatment for hemorrhoids were mostly men (66%) between the ages of 35-60 years. Rectal bleeding and glair (30%) was the most obvious symptom. The ethnobotanical survey identified 48 plants including 35 woody and 13 herbaceous plants used by trade-practitioners to treat hemorrhoids. Piper umbellatum, Antrocaryon klaineanum, Trilepisium madagascariense, Myrianthus arboreus, Irvingia gabonensis, Morinda lucida, Spathodea campanulata, Alchornea cordifolia, Mangifera indica and Baillonella toxisperma were the most used species. These plants were rich in many bioactive compounds amongst which phenolic compounds, coumarines and triterpenes were the most represented.