The LD50 values of sponge Sigmadocia fibulata and Suberites carnosus were evaluated as O= Survival and X= Death. For both the samples we found that the LD50 is greater than 2000 mg/kg. In histopathological examinations of liver the crude extract Sigmadocia fibulata showed congested vasculature and focal minimal degenerative changes in hepatic parenchyma with cellular swelling and vacuolar changes of hepatocytes were noted, where as in normal control and rats treated with crude extract of Suberites carnosus, no metabolic or pathological lesions in liver tissue sections were observed. In kidney tissue rats treated with crude extract of Suberites carnosus showed focal congestion of vessels in renal parenchyma. The focal areas showed cellular swelling in renal tubules with presence of granular cytoplasmic changes in the epithelium of tubules showing absence of inflammatory changes in the section; where as in normal control and rats treated with Sigmadocia fibulata no metabolic or pathological lesions in kidney tissue sections were observed. In the histological examinations of heart, lung, and brain tissues no observable changes were noted in normal control and experimental rats, treated with crude extract of Sigmadocia fibulata and Suberites carnosus.