There are many potential harms associated with self-medication such as, toxicity, drug resistance, serious adverse effects, drug interactions, drug abuse and dependence, still it is being practiced widely for various reasons such as to save time & cost, to prevent symptoms or to treat minor illnesses, unavailability of doctors etc. The endeavor of this study was to describe and evaluate the self-medication practices, reasons behind self-medication & use of antibiotics without prescription among pharmacy students in northern India, using a structured questionnaire. The study was conducted in March 2015 with in 100 students from pharmacy field & related disciplines. Data concerning demographic characteristics, medication use habit, and self-medication were collected through a validated questionnaire with open and closed-ended questions. Medication knowledge was evaluated by the number of correct answers. Paracetamol & NSAIDs (89%) were found to be most frequently used OTC medicines for headache/ Fever. around 60% students consider self-medication for GI disease, 33% for skin disease & local injury, and 32% for ophthalmic ailments. Pharmacy students has significant knowledge about drugs. they were familiar about correct name, dose, associated side effects of drugs. Friends, Relatives and medicine retail shops are evaluated to be responsible for promoting self-medication among the pharmacy students. The presence of pharmacists in all medicine retail outlet can play a significant role to prevent self-medication harm. Immediate actions to promote healthcare under qualified Health Care Professionals should be considered by policy makers.