Kalamegha (Andrographis paniculata) is a medicinal plant conventionally used for the treatment of anti-inflammatory, antioxidant, antibacterial, antiparasitic, antispasmodic, antidiabatic, anti carcinogenic, Hepatoprotective ,antipyretic, antidiarrhoeal, nematocidal, anti-HIV and numerous infectious diseases ranging from malaria to dysentery. The plant is extensively used in ayurvedic and homeopathic systems of medicines. The drugs are said to be lord of all plants, as it conquers number of diseases. In Samhita and Chikitsa grantha, Kiratatikta and Kalamegha drugs are very frequently indicated in diseases like Daah, Kasa, Jawaragan, Swans, Udar. In the present work an attempt has been made to emphasize the folk herbal medicine which will aid in the identification of fresh as well as dried crude sample of leaves anatomically and Pharmacognostical. The study deals with macroscopic, microscopic, phytochemical analysis and TLC fingerprinting. These studied will provide referentially information for correct identification and for standardization.