The Syndrome X or metabolic syndrome, a cluster of metabolic and cardiovascular disorders, is typically characterized by abdominal obesity, insulin resistance, hyperglycemia, atherogenic dyslipidemia and hypertension. As the Syndrome X and diabetes mellitus has increased in the recent decades, the importance of early detection of insulin resistance is crucial. Therefore, the aim of this study was to elucidate the association of HbA1c with Syndrome X with insulin resistance using HbA1c as marker. This was a prospective, case control study and including 100 subjects. Out of which, 50 subjects were the patients of Syndrome X and 50 were normal control subjects. Venous whole blood specimen of case group was collected. Samples were also taken from healthy age and sex matched controls. All samples were analyzed for Glycated Haemoglobin (HbA1c) on HbA1c Analyzer. HbA1c level was significant (p<0.0026) in Syndrome X patients. Our results suggest that HbA1c may be a marker for metabolic syndrome and may identify in a certain degree insulin resistance in subjects.