Background: Caffeine is an alkaloid occurring naturally in plants. It is a widely consumed food/drug constituent and has well-documented benefits like improvement in mental alertness, concentration, fatigue and athletic performance. The primary objective of this study explores the behavior and attitude of Saudi people in Northern Border Area regarding caffeine intake. The secondary objectives of the study are to determine the mostly used caffeinated products, the frequency of caffeine use and the study group background about drug interaction with caffeine. Methods: Descriptive cross-sectional design was used to carry out this study from December 2015 to March 2016. The study was conducted in different areas in Northern Border region. The sample comprised of 454 Saudi persons aged between 15 and 60 years. Data was collected through a structured paper questionnaire, mentioning the purpose of the study after taking oral consent. Statistical analysis was done by utilizing MS EXCEL program functions. Results: The males represented more than half (57%) of the study group. Participants with university education represented 48.5% and secondary education represented 42% of study population. Only 11% of this study participants informed about having chronic diseases. Coffee is the most preferred drink containing caffeine (51%), followed by carbonated soft drink (22.5%). 26% began consumption at age group of 8 to 16 years and 28% began at age group of 16 to 18 years. 39% of participants have no certain cause for caffeine consumption. 31% of study group drink one cup/bottle per day, while 25% of study group drink two cups/bottles per day. 28% participants experience some symptoms when quitting or delaying caffeine drink mainly headaches (18.1%). 56% participants use more than one type of caffeine. The cost is not a significant factor in caffeine product choice (77%). 69% of participants reported that their friends have no effect on the choice for caffeine type. .................