Background: Hypothyroidism is one of the major endocrine diseases involving various organs including musculoskeletal systems. Musculoskeletal involvement has led to varying degree of morbidity. The mechanism of musculoskeletal involvement is probably auto-immune related. Methods: This was a prospective study of the patients with diagnosis of hypothyroidism referred from the endocrine clinic with various musculoskeletal complaints. The duration of the study was one year (July 2018-June 2019). All the patients with hypothyroidism with musculoskeletal complaints were included. Excluded were patients with other endocrine and infectious diseases. Results: Eight hundred and fourty rheumatology patients were seen over the study period. Females constituted 72.6%. One hundred and twenty-six hypothyroid patients were seen during the period comprising 112 (88.9% females and 14 (11.1%) males. The mean age of patients was 44 ± 8 years. Most patients (90.3%) presented at the rheumatology clinic after the third year of diagnosis of hypothyroidism. Generalized body pain was the leading non-articular disease, while myopathy ranked first among muscle and articular disorders. Normocytic normochromic anaemia, abnormal lipid profile and elevated creatine phosphokinase (CPK) enzyme were the predominant laboratory abnormalities. Conclusion: Due to overlapping of symptoms of hypothyroidism over those of systemic auto-immune diseases, it is therefore important to perform thyroid function test in patients presenting with musculoskeletal complaints.