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Saudi Journal of Medical and Pharmaceutical Sciences (SJMPS)
Volume-6 | Issue-01 | 50-52
Original Research Article
Formulation and In-vitro Evaluation of Mouth Dissolving Tablets of Aceclofenac
Soumi Pramanik, Sudipta Das, Debjani Das
Published : Jan. 17, 2020
DOI : 10.36348/sjmps.2020.v06i01.008
Abstract
Objective: The objective of the study was to formulate a mouth fast dissolving tablets of Aceclofenac and its invitro evaluation. Materials and methods: Aceclofenac mouth dissolving tablets were prepared by direct compression method. Three batches were prepared. The tablets were evaluated by hardness, friability, disintegration test, wetting test and in-vitro dissolution method. Results: The granules were evaluated by determining the angle of repose (24.58±0.602° to 30.29±0.327), bulk density, tapped density, Hausner ratio, and Carr’s index. The prepared Aceclofenac tablets were subjected to measurement of hardness (4.2 ±0.08, 4.5 ±0.06 and 5.5 ±0.05 kg/cm2 respectively), friability (0.88±0.02, 0.67±0.08, and 0.55±0.07 % respectively), disintegration, wetting and invitro release study. All parameters were satisfactory within limit. Conclusion: So, it is concluded that the F3 batch is better than another batch. The release pattern is depending upon the amount of Sodium starch glycolate added. Though long-term stability study is required for future development of these formulations.
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