Objective: To assess the iron status in children with sickle cell disease (SCD) and trait (SCT). Design: Prospective, observational, descriptive study. Setting: Referral tertiary hospital in the state of Jharkhand. Methods: 108 consecutive patients of SCD and trait were enrolled and complete hemogram, serum iron and serum ferritin were measured. Results: Patients with SCT were more at risk of having iron deficiency (ID) than SCD.ID was present in patients who had not received or received <5 units of blood transfusion (BT).High iron level was found in all the patients who had received more than 10 units of BT. Serum Ferritin level had linear relationship with units of BT. Conclusion: Patients with SCT were more in number than that of homozygous SCD (2.6:1). Patients with SCT had more chances to have ID than homozygous SCD.