Very few ethnic groups in Cameroon have been subjected to ethnobotanical surveys and data on plants having medicinal properties against sinusitis which are very scarce. The current study is about exploring the Cameroonian flora in order to promote traditional medicine in the treatment of this affection. Ethnobotanical surveys were conducted among traditional healers and herbalists from villages and local markets in the Centre, Littoral, East and West provinces in order to identify the plants used by these four major cultural groups in Cameroon to treat sinusitis. After recipe characterization, the plant specimens were harvested and identified. Their floristic characterization and finally determining the composition of their bioactive metabolites were done. A total of 78 recipes involving 52 medicinal plant species were identified for sinusitis treatment; these recipes were prepared using plant combinations. These plants belong to 29 families, the most represented belong to the Fabaceae (7 species), Rutaceae (5 species) and Rubiaceae (4 species) families. 73.00 % are woody plants from which the bark (56.00 %) is mainly collected. Fruits of Massullaria acuminata (29 occurrences), bark of Piptadeniastrum africanum (17), Erythrophleum suaveolens (9), Mammea africana (9), Cylicodiscus gabunensis (6) and leaves of Nicotiana tabaccum (5 occurrences) are the most commonly used organs to prepare the recipes which are mainly administered by nasal instillation (60.77%). The bark of Antrocaryon klaineanum (6 occurrences), the stems of Costus afer (6) and the fruits of Citrus lemon (5 occurrences) are used as plant combinations. These plants are forest species (62.00 %) with regional distribution (40.00 %) whose diaspores are spread by zoochory (97.00 %). They contain many bioactive compounds, in particular phenolic compounds responsible for their pharmacological activities and thus justifies their use in the traditional treatment of sinusitis.