Objective: The present investigation was aimed to assess the effect of Forskolin (FL) against cognitive impairment produced by scopolamine in rats using various behavioral models such as Y-maze, Novel object recognition test (NORT) and some biochemical markers of Alzheimer’s disease. Methods: Rats were assigned to six different groups, each group consisting of six animals. The normal animals received distilled water, 10 ml/kg per orally (p. o.), FL (250, 500,750 µg/kg, p. o.) was administered once daily for two weeks. One the last day of treatment, 90 min. post- administration of the last dose of forskolin, amnesia was produced in rats by administration of scopolamine (3 mg/kg) intraperitonealy (i.p.). Then rats were trained to Y-maze and NORT protocol. Short term memory behavioral responses were recorded after 90 min of training session (retention memory) and 24 h after training (long term memory). Donepazil (3 mg/kg, p. o.) was used as a standard and was administered for 14 days to positive control groups. Biochemical parameters such as reduced glutathione (GSH), Lipid Peroxidation (MDA) and acetylcholinesterase activity were analyzed. Results: Administration of different doses of FL (250, 500,750 µg/kg) once daily for two weeks significantly improved the learning ability and the retention of learned memory in Y-Maze and NORT. Moreover, pre-treatment with FL significantly restored increased lipid peroxidation; normalized glutathione and increased acetylcholinesterase activity. Conclusion: Forskolin enhances cognitive performances of rats against memory impairment by forskolin. Antioxidant activity, mainly inhibition of reactive oxygen species generation by natural diterpenoid compound forskolin advocates its therapeutic efficacy in treating neurodegenerative diseases.