Controlled animal experiment was done at Department of Pharmacology, R. G. Kar Medical College and Hospital after getting permission from institutional animal ethics committee to find out a drug with good analgesic & safety profile for long term use in high risk population like hepatic, cardiac, hypertensive, diabetic patients. Flupirtine maleate, Tramadol hydrochloride and Paracetamol these three compounds have known analgesic property of their own and they are relatively safe than NSAIDS and opioids. Conventional Hot plate and Tail flick methods were used to access the analgesic effects of drugs. Total number of 36 screened Swiss albino mice were taken in the experiment. Mices were divided into six groups from Ato F with six mices in each group, where A is the control, B,C,D,E,F are the flupirtine(B), tramadol(C), paracetamol(D), combined half(E) and comboned full doses(F) of these three drugs. Result were noted at 20, 60 and 90 minutes intervals. Analgesic effects between these groups were compaired and p value were extracted. All the drugs individually as well as in combinations with their half and full doses showed an increase reaction time in comparison with control. Combinations in half and full doses also showed more nalgesic property than individual drugs. So, we may conclude that combination of flupirtine, tramadol and paracetamol have supra additive analgesic effects.