A new simple, accurate, precise and reproducible RP-HPLC method has been developed for the simultaneous estimation of ibuprofen and famotidine in naturally sweet dispersible pediatric tablets using C 18 column in isocratic mode. Methanol: buffer (90:10), pH 5, 25 mM; flow rate 0.9 ml/min; column length: 25cm is optimized. The flow rate was 1.0 ml/min and detection wavelength was carried out at 284 nm. The retention times of ibuprofen and famotidine were 5.293 min and 2.543 minutes respectively. The method was linear over the concentration range for ibuprofen 50-450µg/mL and 2-18µg/mL for ibuprofen and famotidine respectively. The recoveries of ibuprofen and famotidine were found to be in the range of 99.037-100.766% and 99.703-100.433% respectively. The validation of method was carried out utilizing ICH-guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form.