Medication therapy to Chronic Kidney Disease patients is complex because of the co morbidities and the major risk associated with these patients. A prospective, cross sectional study was conducted for a period of 6 months in a tertiary care hospital. A total of 130 patients, aged 18 years or older, diagnosed with all stages of Chronic Kidney Disease were included in the study. Patient data were collected from the patient medical records, the prescriptions were analyzed and the drug related problems were identified and classified according to Hepler and Strand. Descriptive analysis was done for age, gender, stages, drugs and Drug Related Problems. A total of 1454 drugs were prescribed for the patients with an average of 13.3±3.53 drugs per prescription. An average of 1.25±1.23 Drug Related Problems per prescription were observed among the study population. The most common Drug Related Problems identified was Adverse Drug Reactions (11.53%) and Drug combinations to use with caution and need close monitoring (11.53%), followed by over dose 9.23%. Other Drug Related Problems identified were untreated indication 7.69%, Drug without indication 3.08%, improper drug selection 1.53%, Treatment duplicity 0.76%, and potential Drug interactions 80.00%.Continual identification and resolution of Drug Related Problems in Chronic Kidney Disease could play a vital role in achieving better clinical outcomes.