This was a prospective, multicenter, observational and non-interventional epidemiological study. Five hundred and fifty (550) male and female patients between 18 to 65 years with an established liver cirrhosis were enrolled. Patients recruited underwent screening of mental state by Mini Mental State Examination (MMSE). Patients with a score of MMSE > 24 were required to undergo Psychometric Hepatic Encephalopathy Score (PHES) examination to diagnose MHE. Subjects with an abnormal PHES score of -5 or less were diagnosed with MHE. Subjects with established MHE and those without MHE were assessed for quality of life (QoL). QoL was assessed for Health-Related Quality of Life (HRQoL) using the SF-36 questionnaire. The proportions for the physical component scores (PCS) and mental component scores (MCS) of the SF-36 were calculated and compared. Among the diagnostic scores the mean MMSE score was 27.5 ± 1.8. Of these subjects, 451 were found to have a MMSE score of 24 or higher and were administered the PHES examination. Two hundred and fifty-six (256) subjects (56.8%) had an abnormal score of ≤ -5 and were diagnosed as having minimal hepatic encephalopathy (MHE). Subjects were tested for quality of life through SF-36 questionnaire. Subjects with established MHE were found to have a significantly lower physical component score (PCS) compared to those without MHE. Frequency of Minimal Hepatic Encephalopathy was found to be 56.8% of patients with Chronic Liver Disease presenting to clinics. Impact of MHE on physical component of quality of life may be of clinical relevance.