Bushke-Lowenstein Tumor Giant or Condyloma Acuminata is a rare neoplasm induced by an oncogenic human papilloma virus (HPV 11 and 6). It is a sexually transmitted disease. Despite of its indolent character it can probably degenerate to an aggressif epidermoid carcinoma like in our observation. We report the case of a patient who developed this tumor with locoregional destruction .The Aim of this work is to describe this pathology via a literature review.