This study was carried out to investigate the antioxidant and serum lipid effects of the leaf extract of Momordica charantia on male wistar rats. The animals were divided into three (3) groups of six (6) rats each. Group one (1) served as control and received distilled water. Group two (2) and group three (3) were treated with 200mg/kg bw and 400mg/kg bw of the hydromethanol extract respectively. Extract was orally administered once daily for 30 days. The results obtained showed that the extract caused a significant increase in the catalase and gluthathione enzyme activity and a significant reduction of malondialdehyde level. There were no significant alterations of low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), triglyceride and total cholesterol concentrations. The lipid ratios like the Castelli’s Risk Index I and II were not affected. This study showed that, the leaf extract of Momordica charantia demonstrated anti-oxidant effects but did not influence risk ratios for developing cardiovascular diseases in wistar rats.