Mucormycosis is an opportunistic fungal infection primarily caused by fungi belongs to class Zygomycetes, order Mucorales and family Mucoracae. It is common in patient with diabetes mellitus (DM), systemic immunocompromise and iron overload. Here by we present a case report of Rhino- Orbito Cerebral Mucormycosis which is fatal if undiagnosed and unterated in correct time and way.