Background: Neonatal hypoglycaemia is a common metabolic abnormality in newborns and may be associated with neurological injury and death, particularly in high-risk neonates. This study assessed the burden and clinical correlates of low blood glucose among neonates admitted to the Special Care Baby Unit (SCBU) of the University of Benin Teaching Hospital (UBTH). Methods: This retrospective cross-sectional study reviewed SCBU records from 1 January to 31 December 2024. Of 623 records identified, 219 neonates had sufficiently complete records and documented blood glucose values for analysis. Data were analysed with SPSS version 27. Categorical variables were summarized as frequencies and percentages, and associations were assessed using chi-square tests. Hypoglycaemia was defined in the source dataset as blood glucose ≤40 mg/dL, with values <30 mg/dL classified as severe and 31–40 mg/dL as moderate. Results: Of the 219 neonates analysed, 121 (55.3%) were male. Preterm low birth weight was the commonest recorded diagnosis (52.5%), followed by neonatal sepsis (37.4%) and neonatal asphyxia (10.0%). Severe hypoglycaemia occurred in 88 (40.2%) and moderate hypoglycaemia in 80 (36.6%), giving a prevalence of 76.7% among analysed neonates. Ninety neonates (41.1%) died. Blood glucose category was significantly associated with mortality (χ²=15.91, p=0.007) and diagnosis (χ²=24.21, p=0.0071), but not with gestational-age category (χ²=30.18, p=0.067) or sex (χ²=5.0, p=0.60). Conclusion: Low blood glucose was frequent among neonates with complete glucose records admitted to this tertiary SCBU and was associated with mortality and diagnostic category. The findings support early glucose surveillance and prompt management in high-risk admitted neonates, while the retrospective, selected-record design limits generalization of the prevalence estimate.