Background: Quality of life (Qol) provides an insight on how patients perceive their well-being, daily functioning and treatment tailored to improve their overall health such as self-care. This study was designed to assess the Qol of patients with Benign prostatic hyperplasia (BPH) in selected hospitals in Akwa Ibom State, Nigeria. Materials and methods: This prospective cross-sectional study among 251 patients was conducted in selected hospitals using the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire. Data on Qol across the main four domains such as physical health, psychological well-being, social relationships, and environmental context were retrieved and analyzed using descriptive statistical tools. Results: Out of 251 respondents the majority 83 (33.1%) were within the age group of 60 to 69 years and the least 36 (14.3%) were in the age bracket of 70 years and above. Large proportion 185 (73.7%) of the respondents we're married and the least 13 (5.2%) were single. The grand total mean for general quality of life is 1.97 ± 0.67. The grand mean value for physical well-being is 2.94 ± 0.84. The grand mean value for psychological well-being is 2.86 ± 0.86. The grand mean value for social relationship is 2.65 ± 0.78 and the grand mean value of quality of life of patients with BPH in the selected hospitals is 2.62 ± 0.69 indicating moderate level quality of life. However, the patients were not satisfied with their general well-being and quality of life as indicated in low means scores and standard deviation (Mean=1.97, SD=0.67) and environmental well-being (Mean=2.39, SD=0.77) and items in social relationship. Conclusion: The quality of life of patients with BPH was found to be moderate generally, indicating that patients were able to maintain satisfactory physical, emotional, and social well-being despite the chronic nature of the condition.