Background/Introduction: Postoperative recurrence of Crohn's disease is frequent despite therapeutic advances. Early ileocolonoscopy, evaluated using the Rutgeerts score, is the reference standard for detecting endoscopic recurrence, which strongly correlates with the risk of clinical relapse [1]. Materials and Methods: This retrospective study included patients with Crohn's disease followed up between 2012 and 2025 who underwent an ileocecal or ileocolonic resection. Endoscopic recurrence was defined as a Rutgeerts score ≥ i2 during an ileocolonoscopy performed between 6 and 12 months postoperatively [1,2]. Results: Endoscopic recurrence was observed exclusively in patients who did not receive postoperative prophylactic treatment. No cases of recurrence were observed in patients treated with azathioprine or infliximab. Conclusion: The absence of postoperative prophylactic treatment appears to be a major risk factor for early endoscopic recurrence [2–4].