Angular cheilitis is a prevalent, multifactorial inflammatory lesion at the oral commissures that occurs with notable frequency in patients undergoing prosthodontic rehabilitation. Reduced occlusal vertical dimension, ill-fitting dentures, xerostomia, and Candida overgrowth are the principal predisposing factors. Diagnosis relies on clinical assessment supported by microbiological sampling to differentiate fungal from bacterial etiologies. Management requires a combined approach encompassing antifungal pharmacotherapy, prosthetic correction, including restoration of the occlusal vertical dimension, and optimization of oral and denture hygiene. The published evidence base for specific treatments remains limited, with very few randomized controlled trials available. Prosthodontists should adopt a systematic diagnostic framework that addresses both microbial and mechanical etiologies to reduce recurrence and improve the patient’s quality of life.