Despite the growing recognition of the transformative benefits of electronic procurement (e-procurement) systems, their adoption and effective implementation in developing countries, particularly Nigeria, has been considerably slow and uneven. Hence, the effectiveness of E-Procurement systems in enhancing supply chain efficiency in Kogi State, Nigeria, was investigated in this study. The study participant were workers in Kogi State ministries, departments, and agencies (MDAs) and questionnaires through electronic platforms/online survey platforms was used to gather data from the respondents, after which the data were analysed using Statistical Package for Social Sciences (SPSS) software v23. Results from the findings showed that majority of the respondents are procurement officers (81.8%), with 4-6 years working experience (63.6%). Also, 54.5% majority of the respondents stated that the e-procurement system has reduced procurement led time to a moderate extent, whereas more than half of the respondents (54.5%) stated that the e-procurement system has reduced procurement costs to a moderate extent. More also, 63.6 % majority of the respondents stated that e-procurement system significantly enhanced transparency and accountability in their organizations to a large extent. The major challenges usually encountered when implementing e-procurement systems in Kogi State MDAs were found to be lack of proper infrastructure (26.1%) and poor staff training and support (26.1%). Hence, it was recommended that there should be proper strengthening of digital infrastructure, adequate capacity building and training, change in management strategies, and stakeholders’ engagement among Kogi state MDAs, which will improve E-Procurement systems and supply chain efficiency.